Malar J. Nov 26;17(1) doi: /sy. Aspidosperma pyrifolium, a medicinal plant from the Brazilian caatinga, displays a high. Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan. Find technical and marketing information for lesser-used tropical timber species, LUS. Learn more on our Jitichuriqui (Aspidosperma pyrifolium) page.

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Anti-inflammatory effects of red pepper Capsicum baccatum on carrageenan- and antigen-induced inflammation. Scientific Name Aspidosperma pyrifolium Mart. Several mechanisms are involved in the systemic manifestations caused by the venom of T. We also evaluated the cytotoxic effects of this extract, using the 3- 4,5-dimethythiazolyl -2,5-diphenyl-2H-tetrazolium MTT assay and the results revealed that oyrifolium extract is safe.

The presence of rutin pyrkfolium confirmed by comparison with reference standard data. Conflicts of Interest The authors declare no conflict of interest.

Flavonoidglycoside acids from flowers of Arnica montana und Arnica chamissonis. Please review our privacy policy. The Mass bank database Available online: These results exhibited the anti-inflammatory action of the aqueous extract of A.

The cell viability of the 3T3 cells was analyzed after 48 and 72 h of incubation with aqueous extract of A. Figure 4 A shows that the dose of 7. Further studies are required to test the potential application of this extract and identified compound in the therapy of inflammatory conditions and of scorpion envenomation.

Anti-inflammatory activity of aqueous extract AE from the leaves of Aspidosperma pyrifolium and rutin against carrageenan-induced peritonitis model.

None of the crude extracts or fractions was cytotoxic to normal monkey kidney and xspidosperma a human hepatoma cell lines, or human peripheral blood mononuclear cells; the MDL50 values of all the crude bark extracts and fractions were similar or better when tested on normal cells, with the exception of organic and alkaloidic-rich fractions from stem extract. Several species of Aspidosperma plants are referred to as remedies for the treatment of malaria, especially Aspidosperma nitidum.


Serum levels of cytokines in patients envenomed by Tityus serrulatus scorpion sting. Published online Oct The administration of aspidospema should occur as soon as possible so there is the neutralization of systemic effects caused by envenomation.

JITICHURIQUI (Aspidosperma pyrifolium)

The aim of this approach was to evaluate in vivo the ability of the aqueous extract of Aspidosperja. A survey from the literature of plants used to treat scorpion stings. Tityus serrulatus venom increases vascular permeability in selected airway tissues in a mast cell-independent way. Popular reports in farms in the State of Rio Grande do Norte, Brazil, described that the old-aged-people used the species for the treatment of dizziness, urinary disorders, wound healing and inflammation.

Aspidosperma pyrifolium Mart. — The Plant List

In its UPLC-HRMS analysis this fraction was shown to have two major components compatible with the adpidosperma alkaloid Leucoridine B, and a novel compound, which is likely to be responsible for the activity against malaria parasites demonstrated in in vitro tests.

The data suggest that the doses of A. De Souza Lima M. Saline solution Groups 1 and 2, i. Venom and Antivenom Lyophilized T. The dried and ground leaves, which were left in contact with boiling water for 15 min, were extracted by decoction in a 1: Resistance To Impregnation It is moderately permeable. Histopathology Analysis Edema and vascular ectasia were observed in the lung tissues of envenomed mice Figure 6 B.

Recent studies by our group have demonstrated the beneficial effect of the use of plant extracts in the local treatment of snakebite [ 13 ], but there are few studies exhibiting the effectiveness of such treatment in envenomation induced by scorpion sting [ 1014 aspidsperma, 1516 ]. Detection at nm. LC-DAD-MS analyses were performed to determine the molar mass of the compounds under investigation conducted by qualitative liquid chromatography profile.

Abstract Scorpions of the genus Tityus are responsible for the majority of envenomation in Brazil, the Tityus serrulatus species being the most common and dangerous in South America. Both exhibit similar mass spectrum but disagree with the retention time [ 29 ]. The extract and rutin showed a reduction in the cell migration into the peritoneal cavity, and in the same way the envenomated animals also showed reduction of edema, inflammatory cell infiltration and vasodilation in lungs.


Table 1 summarizes the anti-inflammatory activity of aqueous extract and rutin in carrageenan-induced peritonitis model. Anti-malarial activity of selected extracts and fractions that presented in vitro activity were tested in mice with a Plasmodium aspidospermaa blood-induced infection. Simultaneously, the mice received an i. Simultaneously, the animals were injected i. After six hours of envenomation induction, the mice were euthanized; 2 mL of cold sterile saline were injected in the peritoneal cavity and, after 30 s of gentle massaging, peritoneal fluid was collected.

Steps 17 – Tree Conservation Database.

Implications for inflammation, heart disease, and cancer. There are so far no studies focusing on A. Aqueous extract of A.

Isolation and characterisation of the monoterpenoid indole alkaloids of Aspidosperma pyrifolium.

Dried Botanical ID

Finally, we revealed that the lungs of animals treated pyrifloium rutin and aqueous extracts of A. Grain This timber usually has straight or interlocked grain. Clinical consequences of Tityus bahiensis pyrifoliumm Tityus serrulatus scorpion stings in the region of Campinas, southeastern Brazil.

Antitumor effect of laticifer proteins of Himatanthus drasticus Mart. Four hours after peritonitis induction, mice were euthanized; 2 mL of cold sterile saline were injected in the peritoneal cavity and, after 30 s of gentle massaging, peritoneal fluid was collected. Others symptoms displayed by victims of scorpion accidents are fever, restlessness, excessive salivation, lacrimation, increased gastrointestinal motility, respiratory, cardiac arrhythmias, acute pulmonary inflammation, hypertension followed by hypotension, heart failure, and cardiogenic shock.

Insulin-like effects of Bauhinia forficata aqueous extract upon Tityus serrulatus scorpion envenoming. The Apocynaceae family has considerable economic and medicinal importance [ 1718 ]. After four hours, the peritoneal wash was performed with PBS and the number of cells was determined using a Neubauer chamber.