Politics

10 PHENANTHROLINE MOETIY PDF

1,Phenanthroline forms a stable complex with Fe(II) ion called ferroin, which is used as an indicator in Fe(II) salt titrations. Ferroin is also. Structure, properties, spectra, suppliers and links for: phenanthroline, 1,Phenanthroline [ACD/Index Name] [ACD/IUPAC Name]. preferably any one of embodiments 1, 2 and 10, wherein ALK and ALK’ are both propylene, moetiy is typically an antagonist; if under such conditions the second targeting moiety is Tris(4,7-diphenyl- 1,phenanthroline)ruthenium( II).

Author: Nejin Talmaran
Country: Pacific Islands
Language: English (Spanish)
Genre: Health and Food
Published (Last): 28 March 2007
Pages: 207
PDF File Size: 3.26 Mb
ePub File Size: 13.68 Mb
ISBN: 488-8-59087-115-9
Downloads: 35941
Price: Free* [*Free Regsitration Required]
Uploader: Kajikus

In an embodiment and as preferably used herein, C 3 -C 8 heterocyclo refers to a C 3 – C heterocycle group defined above wherein one of the carbocycles group hydrogen atoms is replaced with a bond. R 3R 4 and R 5 are each and independently selected from the group consisting of hydrogen and methyl under the proviso that one of R 3R 4 and R 5 phenanthrolinee of the following formula 3.

In an embodiment and as preferably used herein, C 3 -C 8 carbocyclo refers to a C 3 phenantrholine C 8 carbocycle group defined above wherein one of the carbocycles group hydrogen atoms is replaced with a bond. The nature of the formed linkage depends on the reactive groups involved in the forming of the linkage, as will be appreciated by a person skilled in the art.

Biol,29, ; Blauenstein et al, Cancer Biother.

Set,18, ; Cescato et phenanthrolibe, J. The conjugate of any one of embodiments 1 phenanthroilne 78, for use in a method for the identification of a subject, wherein the subject is likely to respond or likely phebanthroline to respond to a treatment of a disease, wherein the method for the identification of a subject comprises carrying out a method of diagnosis using the compound of any one of embodiments 1 to 78, preferably a method for the diagnosis of a disease as described in any one of embodiments 79 to In other projects Wikimedia Commons.

In an embodiment and as preferably used herein, a theragnostically active compound is a compound which is suitable for or useful in both the diagnosis and therapy of a disease.

In a preferred embodiment, the two reactive groups provided by the adapter moiety are different. The conjugate of any one of embodiments tophenanfhroline the disease is selected from the group comprising tumors and hematological malignancies.

  DREAMLIGHT TRILOGY PDF

Also in accordance with the function of an adapter moiety in a conjugate of the invention, the reactive group s borne or provided by the adaptor moiety are of importance.

In another embodiment of the conjugate of the invention the conjugate comprises, in terms of an adapter moiety, only a first adapter moiety AD2 and a third adapter moiety AD3. The conjugate of any one of embodiments 2 to 42, wherein the Effector moiety EM is linked, preferably covalently linked to the branching moiety Y. phrnanthroline

The second linkage to the carboxylic acid group is an amide linkage and the corresponding reactive mortiy as provided by the adapter moiety is a primary or secondary amino group. In a preferred embodiment thereof, the adapter moiety forms a thioether linkage with a sulfur atom of the targeting moiety.

O-Phenanthroline | C12H8N2 – PubChem

Dasiglucagon Glucagon Oxyntomodulin Antagonists: Because of this, this kind of compound of the prior art acts as an agonist to NTRl. More preferably, a chemical bond is a covalent bond or a plurality of chemical bonds. S45S60S However, it is well known that the affinity and receptor specificity of the compound as such, i. Redox indicators Chelating agents Phenanthrolines.

The conjugate of any one of embodiments 1, 2, 3, 4, 5, 6 and 7, preferably any one of embodiments 1 and 2, wherein R3, R4 and R5 are each and independently selected from the group consisting of hydrogen and methyl under the proviso that one of R3, R4 and R5 is of the following formula 3. The conjugate of any one of embodiments 79 to 01, wherein the method comprises the administration of a diagnostically effective amount of puenanthroline compound to a subject, preferably to a mammal, wherein the mammal is selected from the group comprising man, phenantholine animals, pets and livestock, more preferably the subject is selected from the group comprising man, dog, cat, horse and cow, and most preferably the subject is a human being.

A method for the diagnosis of a disease in a subject, wherein the method comprises administering to the subject a diagnostically effective amount of a compound according to any one of embodiments 1 to In one embodiment of the conjugate of the invention a compound 2in any of its embodiments, is present in the conjugate of the invention as targeting moiety TMl.

  GATEAUX TOUNSI PDF

phenanthroine

phenanthroline | C12H8N2 | ChemSpider

A “Michael acceptor” is capable of reacting with nucleophiles especially sulfhydryl groups in an addition reaction as exem lified as follows: In an alternative embodiment the two reactive groups provided by the adapter moiety are the same. Even more difficult is designing and synthesizing a radiolabeled derivative of these compounds without diminishing or destroying the original and desired high NTR1 affinity.

Carcinomatosis; Epithelioma, benign; Epithelioma, malignant; Large cell carcinoma. It is within the present invention that the conjugate of the invention comprises a linker moiety. AA-COOH is an amino acid selected from the group consisting of 2-amino- adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.

Phenanthroline

In an embodiment and as preferably used herein, C 2 -C 5 alkylidene means each and individually any of ethane- 1,2-diyl, propane- 1,3 -diyl, propane- 1,2-diyl, butane- 1,4-diyl, butane- 1,3 -diyl, butane- 1,2-diyl, 2-m ethyl-propane- 1,2-diyl, 2-methyl-propane-l,3-diyl, pentane- 1,5-diyl, pentane- 1,4-diyl, pentane- 1,3 -diyl, pentane- 1,2-diyl, pentane-2,3-diyl, pentane-2,4-diyl and any other branched isomer with 5 carbon atoms, preferably C 2 – Cs alkylidene means each and individually any of ethane- 1,2-diyl, propane- 1,3-diyl, butane.

The conjugate of any one of embodiments topreferably any one of embodiments andwherein Effector is a radioactive halogen, wherein preferably the radioactive halogen is covalently bound by Acceptor, wherein Acceptor comprises an aromatic moiety, wherein the aromatic moiety is selected from the group comprising indole and benzene, preferably benzene is substituted with at least one heteroatom, wherein the heteroatom is selected from the group comprising O, N and S.

The dissociation constant is commonly used to describe the affinity between a ligand L such as a drug and a protein P i. Orexin AB Antagonists: It is, however, also within the present invention that the conjugate of the invention does not comprise a linker moiety.